Human Variability in Carboxylesterases and carboxylesterase-related Uncertainty Factors for Chemical Risk Assessment

Modeling of variability and uncertainty in human health risk assessment

Health risk assessments have been carried out worldwide to examine potential health risk due to exposure to toxic contaminants in various environments. In risk assessment, it is most important to know the nature of all available information, data or model parameters. It is observed that available information/data are tainted with uncertainty and variability in the same time, i.e., uncertainty a...

Short Communication Characterization of Recombinant Human Carboxylesterases: Fluorescein Diacetate as a Probe Substrate for Human Carboxylesterase

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and endobiotic metabolism. Although expression of CES1 and CES2 occurs in several organs, their expression in liver and small intestine is predominantly attributed to CES1 and CES2, respectively. We successfully expressed CES1 form ...

Characterization of Recombinant Human Carboxylesterases - Fluorescein Diacetate as a Probe Substrate for Human Carboxylesterase

Human Health Risk Assessment of Cadmium Exposure in Dry Deposition of Atmospheric Dust (Uncertainty Analysis)

 Background and purpose: The atmospheric suspended particulate matter is a major route of human exposure to different kinds of environmental pollutants especially toxic heavy metals. The aim of this study was to assess the carcinogenic and non-carcinogenic risk of cadmium in dry deposition of atmospheric dust in Qazvin, Iran. Materials and methods: Glass traps were used for sampling dry atmosp...

a framework for identifying and prioritizing factors affecting customers’ online shopping behavior in iran

the purpose of this study is identifying effective factors which make customers shop online in iran and investigating the importance of discovered factors in online customers’ decision. in the identifying phase, to discover the factors affecting online shopping behavior of customers in iran, the derived reference model summarizing antecedents of online shopping proposed by change et al. was us...